Equal randomization: Niraparib more effective in the DRD+ biomarker signature (cfr scen 6)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.018, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 50.5, median = 41.2 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.29, hr = 0.72 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.018, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 50.5, median = 41.2 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.29, hr = 0.72 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.018, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 50.5, median = 41.2 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.29, hr = 0.72 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.018, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 50.5, median = 41.2 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.29, hr = 0.72 |
|
|
|
|
|
|
The overall error was 0.154.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.042 0.048 0.080
The overall power was 0.844.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.000 0.000 0.844
| signature | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 3 | 83 |
| futility | 0 | 56 | 63 | 1 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 533 (476, 592) | 368 (200, 529) | 348 (192, 527) | 436 (277, 533) | |
| n_unique | 533 (476, 592) | 368 (200, 529) | 348 (192, 527) | 436 (277, 533) | |
| time_trial | 60 (60, 60) | 60 (48, 60) | 60 (41, 60) | 60 (40, 60) | |
| time_stop | NA (NA, NA) | 28 (17, 53) | 30 (15, 50) | 38 (23, 54) | |
| post_p | NA (NA, NA) | 0.48 (0.08, 0.87) | 0.45 (0.07, 0.86) | 0.97 (0.73, 1) | |
| rate | 0.021 (0.019, 0.022) | 0.021 (0.019, 0.024) | 0.022 (0.019, 0.025) | 0.018 (0.016, 0.019) | |
| TP53- | graduation | 0 | 8 | 5 | 99 |
| futility | 0 | 222 | 221 | 21 | |
| max_n | 0 | 77 | 72 | 83 | |
| n | 290 (250, 330) | 216 (60, 301) | 214 (63, 301) | 246 (132, 302) | |
| n_unique | 290 (250, 330) | 216 (60, 301) | 214 (63, 301) | 246 (132, 302) | |
| time_trial | 60 (60, 60) | 60 (15, 60) | 60 (16, 60) | 60 (36, 60) | |
| time_stop | NA (NA, NA) | 24 (13, 48) | 24 (14, 49) | 38 (17, 55) | |
| post_p | NA (NA, NA) | 0.46 (0.09, 0.88) | 0.45 (0.09, 0.88) | 0.93 (0.57, 1) | |
| rate | 0.021 (0.019, 0.023) | 0.022 (0.019, 0.026) | 0.022 (0.019, 0.026) | 0.018 (0.016, 0.02) | |
| TP53+ | graduation | 0 | 4 | 10 | 92 |
| futility | 0 | 195 | 198 | 27 | |
| max_n | 0 | 6 | 7 | 11 | |
| n | 241 (204, 286) | 184 (65, 250) | 175 (61, 254) | 198 (105, 262) | |
| n_unique | 241 (204, 286) | 184 (65, 250) | 175 (61, 254) | 198 (105, 262) | |
| time_trial | 60 (60, 60) | 60 (20, 60) | 60 (19, 60) | 60 (38, 60) | |
| time_stop | NA (NA, NA) | 28 (16, 53) | 25 (16, 48) | 40 (19, 55) | |
| post_p | NA (NA, NA) | 0.46 (0.09, 0.88) | 0.45 (0.08, 0.88) | 0.89 (0.45, 0.99) | |
| rate | 0.021 (0.018, 0.023) | 0.021 (0.019, 0.026) | 0.022 (0.018, 0.026) | 0.018 (0.015, 0.021) | |
| DRD+ | graduation | 0 | 6 | 4 | 422 |
| futility | 0 | 195 | 194 | 0 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 145 (106, 177) | 88 (50, 159) | 87 (50, 160) | 95 (61, 135) | |
| n_unique | 145 (106, 177) | 88 (50, 159) | 87 (50, 160) | 95 (61, 135) | |
| time_trial | 60 (60, 60) | 60 (27, 60) | 60 (27, 60) | 42 (31, 60) | |
| time_stop | NA (NA, NA) | 34 (24, 53) | 34 (23, 50) | 40 (31, 53) | |
| post_p | NA (NA, NA) | 0.41 (0.08, 0.86) | 0.39 (0.08, 0.85) | 1 (1, 1) | |
| rate | 0.021 (0.018, 0.024) | 0.022 (0.018, 0.027) | 0.022 (0.018, 0.028) | 0.01 (0.008, 0.012) | |
| TEfus+ | graduation | 0 | 3 | 5 | 84 |
| futility | 0 | 176 | 197 | 11 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 199 (162, 229) | 126 (55, 205) | 121 (53, 198) | 156 (93, 205) | |
| n_unique | 199 (162, 229) | 126 (55, 205) | 121 (53, 198) | 156 (93, 205) | |
| time_trial | 60 (60, 60) | 60 (23, 60) | 60 (22, 60) | 60 (43, 60) | |
| time_stop | NA (NA, NA) | 30 (19, 52) | 29 (19, 51) | 42 (29, 56) | |
| post_p | NA (NA, NA) | 0.45 (0.09, 0.84) | 0.45 (0.09, 0.84) | 0.93 (0.59, 1) | |
| rate | 0.021 (0.018, 0.024) | 0.022 (0.019, 0.027) | 0.022 (0.018, 0.026) | 0.017 (0.014, 0.019) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | graduation | 0 | 240 | 236 | 174 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 77 | 72 | 83 | |
| n | 158 (131, 189) | 127 (33, 167) | 128 (36, 169) | 145 (73, 180) | |
| n_unique | 158 (131, 189) | 127 (33, 167) | 128 (36, 169) | 145 (73, 180) | |
| post_p | NA (NA, NA) | 0.48 (0.14, 0.9) | 0.5 (0.09, 0.88) | 0.53 (0.15, 0.85) | |
| rate | 0.021 (0.018, 0.024) | 0.022 (0.018, 0.026) | 0.022 (0.018, 0.026) | 0.021 (0.018, 0.024) | |
| –+ | graduation | 0 | 302 | 320 | 215 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 76 | 66 | 82 | |
| n | 49 (36, 62) | 30 (9, 54) | 29 (10, 52) | 42 (20, 59) | |
| n_unique | 49 (36, 62) | 30 (9, 54) | 29 (10, 52) | 42 (20, 59) | |
| post_p | NA (NA, NA) | 0.48 (0.14, 0.85) | 0.45 (0.1, 0.83) | 0.48 (0.1, 0.84) | |
| rate | 0.021 (0.016, 0.027) | 0.022 (0.016, 0.031) | 0.022 (0.016, 0.032) | 0.022 (0.016, 0.029) | |
| -+- | graduation | 0 | 211 | 221 | 169 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 7 | 11 | |
| n | 100 (80, 129) | 83 (26, 112) | 81 (27, 110) | 89 (45, 119) | |
| n_unique | 100 (80, 129) | 83 (26, 112) | 81 (27, 110) | 89 (45, 119) | |
| post_p | NA (NA, NA) | 0.47 (0.11, 0.86) | 0.46 (0.11, 0.9) | 0.48 (0.13, 0.89) | |
| rate | 0.021 (0.017, 0.025) | 0.021 (0.017, 0.027) | 0.022 (0.017, 0.028) | 0.021 (0.017, 0.025) | |
| -++ | graduation | 0 | 286 | 302 | 217 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 7 | 11 | |
| n | 77 (57, 99) | 53 (18, 84) | 50 (17, 82) | 65 (30, 93) | |
| n_unique | 77 (57, 99) | 53 (18, 84) | 50 (17, 82) | 65 (30, 93) | |
| post_p | NA (NA, NA) | 0.48 (0.12, 0.87) | 0.48 (0.1, 0.86) | 0.46 (0.11, 0.87) | |
| rate | 0.02 (0.017, 0.026) | 0.022 (0.017, 0.029) | 0.022 (0.017, 0.029) | 0.021 (0.017, 0.027) | |
| +– | graduation | 0 | 326 | 325 | 406 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 73 | 68 | 72 | |
| n | 41 (26, 53) | 25 (8, 49) | 25 (8, 49) | 26 (16, 43) | |
| n_unique | 41 (26, 53) | 25 (8, 49) | 25 (8, 49) | 26 (16, 43) | |
| post_p | NA (NA, NA) | 0.39 (0.1, 0.82) | 0.42 (0.11, 0.81) | 0.97 (0.79, 1) | |
| rate | 0.021 (0.016, 0.027) | 0.022 (0.015, 0.032) | 0.021 (0.015, 0.033) | 0.01 (0.006, 0.014) | |
| +-+ | graduation | 0 | 357 | 370 | 414 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 73 | 63 | 72 | |
| n | 40 (25, 54) | 21 (9, 48) | 20 (9, 49) | 27 (15, 43) | |
| n_unique | 40 (25, 54) | 21 (9, 48) | 20 (9, 49) | 27 (15, 43) | |
| post_p | NA (NA, NA) | 0.37 (0.08, 0.77) | 0.39 (0.1, 0.79) | 0.97 (0.72, 1) | |
| rate | 0.021 (0.015, 0.028) | 0.022 (0.016, 0.034) | 0.022 (0.016, 0.033) | 0.01 (0.006, 0.015) | |
| ++- | graduation | 0 | 322 | 322 | 456 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 6 | 11 | |
| n | 31 (19, 42) | 20 (8, 38) | 20 (7, 39) | 20 (10, 31) | |
| n_unique | 31 (19, 42) | 20 (8, 38) | 20 (7, 39) | 20 (10, 31) | |
| post_p | NA (NA, NA) | 0.43 (0.11, 0.8) | 0.37 (0.1, 0.77) | 0.93 (0.65, 0.99) | |
| rate | 0.021 (0.014, 0.028) | 0.021 (0.014, 0.031) | 0.022 (0.015, 0.033) | 0.01 (0.005, 0.016) | |
| +++ | graduation | 0 | 361 | 369 | 465 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 6 | 6 | 11 | |
| n | 30 (17, 44) | 17 (7, 40) | 16 (7, 38) | 20 (10, 32) | |
| n_unique | 30 (17, 44) | 17 (7, 40) | 16 (7, 38) | 20 (10, 32) | |
| post_p | NA (NA, NA) | 0.4 (0.11, 0.77) | 0.42 (0.11, 0.79) | 0.94 (0.7, 1) | |
| rate | 0.021 (0.015, 0.028) | 0.022 (0.014, 0.033) | 0.021 (0.014, 0.034) | 0.009 (0.005, 0.015) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 4 | 3 | 83 |
| time_stop | 44 (26, 55) | 42 (32, 44) | 38 (23, 54) | |
| n_trt | 264 (167, 444) | 323 (251, 337) | 302 (169, 414) | |
| n_control | 396 (216, 498) | 323 (251, 368) | 312 (174, 495) | |
| post_p | 0.95 (0.9, 0.99) | 0.98 (0.95, 0.99) | 1 (0.96, 1) | |
| order | 1.5 (1, 2) | 2 (1.2, 2) | 2 (1, 3) | |
| TP53- | count | 8 | 5 | 99 |
| time_stop | 50 (41, 56) | 44 (38, 57) | 41 (29, 56) | |
| n_trt | 223 (191, 243) | 183 (148, 273) | 181 (123, 258) | |
| n_control | 254 (199, 271) | 186 (162, 276) | 193 (131, 280) | |
| post_p | 0.98 (0.93, 0.99) | 1 (0.98, 1) | 0.99 (0.94, 1) | |
| order | 2 (2, 3) | 2 (1, 2.6) | 1 (1, 3) | |
| TP53+ | count | 4 | 10 | 92 |
| time_stop | 52 (38, 59) | 42 (35, 54) | 44 (29, 56) | |
| n_trt | 164 (124, 214) | 160 (123, 209) | 148 (94, 205) | |
| n_control | 192 (132, 242) | 178 (152, 226) | 170 (105, 235) | |
| post_p | 0.98 (0.97, 0.99) | 0.97 (0.95, 0.99) | 0.99 (0.95, 1) | |
| order | 2 (1.3, 3.4) | 2 (1, 3) | 2 (1, 3.9) | |
| DRD+ | count | 6 | 4 | 422 |
| time_stop | 52 (44, 58) | 43 (38, 52) | 40 (31, 53) | |
| n_trt | 96 (77, 150) | 104 (99, 142) | 93 (65, 131) | |
| n_control | 134 (116, 154) | 114 (101, 164) | 97 (69, 136) | |
| post_p | 0.99 (0.97, 1) | 0.98 (0.96, 1) | 1 (0.98, 1) | |
| order | 2 (1.5, 3.5) | 2.5 (1.3, 3.7) | 1 (1, 2) | |
| TEfus+ | count | 3 | 5 | 84 |
| time_stop | 35 (29, 49) | 53 (32, 57) | 44 (33, 56) | |
| n_trt | 83 (76, 93) | 152 (87, 173) | 124 (80, 160) | |
| n_control | 125 (105, 164) | 184 (98, 198) | 140 (95, 187) | |
| post_p | 0.98 (0.95, 0.99) | 0.97 (0.96, 1) | 0.99 (0.97, 1) | |
| order | 1 (1, 3.4) | 2 (1.4, 2) | 2 (1, 4) |
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 56 | 63 | 1 |
| time_stop | 28 (16, 53) | 30 (15, 51) | 15 (15, 15) | |
| n_trt | 168 (110, 292) | 181 (96, 332) | 110 (110, 110) | |
| n_control | 226 (134, 463) | 249 (120, 398) | 108 (108, 108) | |
| post_p | 0.09 (0.01, 0.19) | 0.07 (0.01, 0.2) | 0 (0, 0) | |
| order | 3 (1.5, 6) | 3 (1, 6.8) | 1 (1, 1) | |
| TP53- | count | 222 | 221 | 21 |
| time_stop | 23 (13, 47) | 23 (14, 49) | 15 (12, 31) | |
| n_trt | 98 (54, 206) | 97 (55, 209) | 62 (53, 132) | |
| n_control | 99 (53, 220) | 100 (55, 214) | 70 (43, 144) | |
| post_p | 0.17 (0.05, 0.27) | 0.19 (0.07, 0.27) | 0.23 (0.07, 0.27) | |
| order | 2 (1, 4.9) | 2 (1, 5) | 1 (1, 2) | |
| TP53+ | count | 195 | 198 | 27 |
| time_stop | 27 (16, 52) | 25 (16, 46) | 20 (14, 33) | |
| n_trt | 93 (53, 201) | 81 (54, 174) | 70 (51, 122) | |
| n_control | 96 (53, 210) | 87 (53, 180) | 68 (49, 120) | |
| post_p | 0.16 (0.05, 0.27) | 0.16 (0.06, 0.28) | 0.2 (0.1, 0.28) | |
| order | 2 (1, 5.6) | 2 (1, 5) | 1 (1, 3.4) | |
| DRD+ | count | 195 | 194 | |
| time_stop | 34 (24, 52) | 34 (23, 50) | ||
| n_trt | 62 (50, 106) | 62 (50, 103) | ||
| n_control | 79 (49, 131) | 78 (48, 120) | ||
| post_p | 0.16 (0.04, 0.27) | 0.16 (0.04, 0.28) | ||
| order | 3 (1, 5) | 3 (1, 5) | ||
| TEfus+ | count | 176 | 197 | 11 |
| time_stop | 30 (19, 52) | 29 (19, 50) | 26 (17, 50) | |
| n_trt | 76 (52, 132) | 71 (52, 146) | 87 (51, 124) | |
| n_control | 93 (52, 171) | 89 (50, 170) | 75 (48, 142) | |
| post_p | 0.16 (0.05, 0.27) | 0.16 (0.05, 0.26) | 0.18 (0.04, 0.29) | |
| order | 3 (1, 5) | 3 (1, 5) | 2 (1, 3) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| time | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | 44 (26, 55) | ||
| n | 58 (33, 125) | 24 (8, 38) | 62 (38, 70) | 48 (28, 70) | 18 (8, 39) | 22 (11, 46) | 26 (9, 36) | 20 (13, 26) | ||
| post_p | 0.68 (0.59, 0.88) | 0.64 (0.58, 0.71) | 0.72 (0.62, 0.82) | 0.64 (0.57, 0.77) | 0.72 (0.62, 0.83) | 0.58 (0.56, 0.81) | 0.63 (0.57, 0.78) | 0.62 (0.57, 0.83) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.019 (0.017, 0.023) | 0.018 (0.01, 0.019) | 0.02 (0.019, 0.022) | 0.017 (0.016, 0.018) | 0.012 (0.009, 0.015) | 0.01 (0.007, 0.019) | 0.011 (0.003, 0.015) | 0.011 (0.003, 0.015) | ||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | 42 (32, 44) | ||
| n | 97 (80, 102) | 22 (17, 25) | 59 (54, 69) | 47 (31, 48) | 23 (20, 29) | 24 (20, 31) | 15 (9, 21) | 18 (16, 24) | ||
| post_p | 0.83 (0.79, 0.87) | 0.61 (0.6, 0.7) | 0.7 (0.59, 0.93) | 0.59 (0.56, 0.87) | 0.68 (0.62, 0.82) | 0.56 (0.56, 0.67) | 0.66 (0.62, 0.85) | 0.56 (0.56, 0.62) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.016 (0.015, 0.018) | 0.013 (0.012, 0.016) | 0.02 (0.015, 0.02) | 0.019 (0.014, 0.026) | 0.015 (0.013, 0.016) | 0.016 (0.015, 0.016) | 0.011 (0.009, 0.014) | 0.015 (0.015, 0.017) | ||
| Niraparib | count | 83 | 83 | 83 | 83 | 83 | 83 | 83 | 83 | |
| time | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | 38 (23, 54) | ||
| n | 84 (54, 142) | 26 (13, 44) | 56 (31, 85) | 41 (23, 63) | 21 (12, 33) | 21 (14, 32) | 16 (9, 25) | 17 (9, 24) | ||
| post_p | 0.72 (0.58, 0.88) | 0.65 (0.57, 0.9) | 0.7 (0.56, 0.88) | 0.64 (0.56, 0.88) | 0.86 (0.6, 0.99) | 0.76 (0.59, 0.98) | 0.8 (0.6, 0.94) | 0.76 (0.56, 0.96) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.017 (0.011, 0.02) | 0.014 (0.006, 0.02) | 0.016 (0.011, 0.021) | 0.017 (0.01, 0.021) | 0.008 (0, 0.014) | 0.008 (0, 0.013) | 0.007 (0, 0.012) | 0.008 (0, 0.014) | ||
| TP53- | Hormone_therapies | count | 8 | 8 | 8 | 8 | ||||
| time | 50 (41, 56) | 50 (41, 56) | 50 (41, 56) | 50 (41, 56) | ||||||
| n | 117 (107, 137) | 38 (36, 47) | 30 (20, 42) | 30 (20, 38) | ||||||
| post_p | 0.8 (0.73, 0.9) | 0.77 (0.72, 0.93) | 0.84 (0.72, 0.9) | 0.81 (0.72, 0.86) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.017 (0.016, 0.018) | 0.015 (0.013, 0.02) | 0.012 (0.008, 0.017) | 0.014 (0.009, 0.015) | ||||||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | |||||
| time | 44 (38, 57) | 44 (38, 57) | 44 (38, 57) | 44 (38, 57) | ||||||
| n | 97 (77, 132) | 42 (23, 44) | 34 (20, 43) | 25 (21, 58) | ||||||
| post_p | 0.73 (0.71, 0.83) | 0.84 (0.75, 0.87) | 0.89 (0.73, 0.93) | 0.86 (0.79, 0.96) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.015, 0.019) | 0.015 (0.012, 0.017) | 0.012 (0.01, 0.017) | 0.011 (0.004, 0.018) | ||||||
| Niraparib | count | 99 | 99 | 99 | 99 | |||||
| time | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | ||||||
| n | 95 (67, 147) | 28 (19, 45) | 25 (16, 35) | 24 (15, 37) | ||||||
| post_p | 0.8 (0.71, 0.93) | 0.76 (0.7, 0.89) | 0.85 (0.72, 0.98) | 0.84 (0.72, 0.98) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.017 (0.012, 0.021) | 0.015 (0.008, 0.021) | 0.008 (0.003, 0.013) | 0.009 (0.002, 0.013) | ||||||
| TP53+ | Hormone_therapies | count | 4 | 4 | 4 | 4 | ||||
| time | 52 (38, 59) | 52 (38, 59) | 52 (38, 59) | 52 (38, 59) | ||||||
| n | 72 (51, 88) | 51 (43, 61) | 27 (16, 32) | 14 (12, 36) | ||||||
| post_p | 0.88 (0.77, 0.91) | 0.82 (0.74, 0.91) | 0.83 (0.79, 0.85) | 0.72 (0.71, 0.81) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.017, 0.022) | 0.015 (0.013, 0.018) | 0.012 (0.007, 0.015) | 0.014 (0.013, 0.019) | ||||||
| Taxel_therapies | count | 10 | 10 | 10 | 10 | |||||
| time | 42 (35, 54) | 42 (35, 54) | 42 (35, 54) | 42 (35, 54) | ||||||
| n | 62 (53, 94) | 50 (27, 71) | 24 (18, 33) | 20 (9, 38) | ||||||
| post_p | 0.83 (0.75, 0.89) | 0.83 (0.71, 0.94) | 0.72 (0.7, 0.78) | 0.75 (0.72, 0.87) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.018 (0.013, 0.02) | 0.014 (0.011, 0.018) | 0.012 (0.007, 0.018) | 0.013 (0.003, 0.017) | ||||||
| Niraparib | count | 92 | 92 | 92 | 92 | |||||
| time | 44 (29, 56) | 44 (29, 56) | 44 (29, 56) | 44 (29, 56) | ||||||
| n | 64 (38, 86) | 47 (28, 75) | 18 (10, 29) | 18 (9, 27) | ||||||
| post_p | 0.8 (0.71, 0.94) | 0.77 (0.71, 0.89) | 0.84 (0.71, 0.97) | 0.85 (0.71, 0.97) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.016 (0.012, 0.02) | 0.015 (0.01, 0.02) | 0.007 (0, 0.013) | 0.008 (0, 0.013) | ||||||
| DRD+ | Hormone_therapies | count | 6 | 6 | 6 | 6 | ||||
| time | 52 (44, 58) | 52 (44, 58) | 52 (44, 58) | 52 (44, 58) | ||||||
| n | 34 (16, 43) | 34 (16, 48) | 24 (12, 34) | 20 (14, 27) | ||||||
| post_p | 0.78 (0.71, 0.87) | 0.79 (0.76, 0.88) | 0.73 (0.65, 0.91) | 0.76 (0.68, 0.92) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.01, 0.019) | 0.015 (0.009, 0.017) | 0.013 (0.009, 0.018) | 0.012 (0.009, 0.015) | ||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | |||||
| time | 43 (38, 52) | 43 (38, 52) | 43 (38, 52) | 43 (38, 52) | ||||||
| n | 32 (27, 40) | 34 (26, 44) | 28 (24, 34) | 18 (12, 28) | ||||||
| post_p | 0.73 (0.71, 0.74) | 0.83 (0.81, 0.94) | 0.74 (0.72, 0.79) | 0.81 (0.73, 0.93) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.018 (0.014, 0.019) | 0.011 (0.006, 0.013) | 0.01 (0.009, 0.014) | 0.009 (0.005, 0.013) | ||||||
| Niraparib | count | 422 | 422 | 422 | 422 | |||||
| time | 40 (31, 53) | 40 (31, 53) | 40 (31, 53) | 40 (31, 53) | ||||||
| n | 25 (17, 40) | 27 (16, 41) | 19 (12, 29) | 20 (11, 30) | ||||||
| post_p | 0.87 (0.72, 0.98) | 0.86 (0.72, 0.98) | 0.77 (0.71, 0.95) | 0.79 (0.7, 0.96) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.008 (0.003, 0.013) | 0.008 (0.003, 0.014) | 0.008 (0, 0.014) | 0.008 (0, 0.013) | ||||||
| TEfus+ | Hormone_therapies | count | 3 | 3 | 3 | 3 | ||||
| time | 35 (29, 49) | 35 (29, 49) | 35 (29, 49) | 35 (29, 49) | ||||||
| n | 5 (5, 20) | 44 (31, 52) | 10 (4, 21) | 22 (10, 25) | ||||||
| post_p | 0.66 (0.64, 0.8) | 0.83 (0.81, 0.84) | 0.73 (0.68, 0.87) | 0.73 (0.68, 0.87) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.01 (0.008, 0.017) | 0.016 (0.013, 0.017) | 0.012 (0.009, 0.014) | 0.009 (0.002, 0.009) | ||||||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | |||||
| time | 53 (32, 57) | 53 (32, 57) | 53 (32, 57) | 53 (32, 57) | ||||||
| n | 38 (9, 45) | 53 (34, 70) | 19 (12, 45) | 28 (21, 33) | ||||||
| post_p | 0.75 (0.69, 0.86) | 0.81 (0.75, 0.93) | 0.72 (0.65, 0.8) | 0.79 (0.75, 0.9) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.008, 0.015) | 0.018 (0.007, 0.021) | 0.014 (0.008, 0.014) | 0.015 (0.012, 0.018) | ||||||
| Niraparib | count | 84 | 84 | 84 | 84 | |||||
| time | 44 (33, 56) | 44 (33, 56) | 44 (33, 56) | 44 (33, 56) | ||||||
| n | 30 (19, 45) | 47 (29, 72) | 24 (15, 38) | 17 (10, 27) | ||||||
| post_p | 0.77 (0.71, 0.92) | 0.76 (0.72, 0.91) | 0.91 (0.73, 0.99) | 0.81 (0.7, 0.98) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.015 (0.008, 0.02) | 0.016 (0.01, 0.02) | 0.008 (0.003, 0.012) | 0.007 (0.001, 0.013) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 56 | 56 | 56 | 56 | 56 | 56 | 56 | 56 |
| time | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | 28 (16, 53) | ||
| n | 48 (26, 113) | 14 (6, 30) | 34 (18, 76) | 22 (12, 41) | 12 (7, 33) | 12 (6, 23) | 10 (4, 20) | 11 (5, 20) | ||
| post_p | 0.34 (0.1, 0.47) | 0.38 (0.24, 0.49) | 0.35 (0.11, 0.49) | 0.37 (0.13, 0.49) | 0.4 (0.13, 0.48) | 0.38 (0.2, 0.47) | 0.42 (0.23, 0.49) | 0.37 (0.11, 0.48) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.021 (0.016, 0.025) | 0.023 (0.015, 0.044) | 0.021 (0.015, 0.031) | 0.023 (0.014, 0.031) | 0.024 (0.012, 0.035) | 0.022 (0.016, 0.04) | 0.023 (0.005, 0.04) | 0.026 (0.011, 0.041) | ||
| Taxel_therapies | count | 63 | 63 | 63 | 63 | 63 | 63 | 63 | 63 | |
| time | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | 30 (15, 51) | ||
| n | 54 (27, 110) | 15 (7, 34) | 32 (17, 72) | 20 (12, 50) | 14 (6, 27) | 13 (6, 21) | 9 (5, 21) | 9 (5, 21) | ||
| post_p | 0.37 (0.08, 0.48) | 0.41 (0.24, 0.48) | 0.38 (0.11, 0.49) | 0.38 (0.11, 0.49) | 0.38 (0.2, 0.48) | 0.38 (0.2, 0.49) | 0.35 (0.16, 0.49) | 0.4 (0.23, 0.49) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.021 (0.017, 0.027) | 0.021 (0.015, 0.034) | 0.021 (0.014, 0.03) | 0.023 (0.016, 0.032) | 0.023 (0.013, 0.036) | 0.022 (0.012, 0.042) | 0.026 (0.013, 0.047) | 0.024 (0.014, 0.041) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||
| n | 37 (37, 37) | 13 (13, 13) | 27 (27, 27) | 10 (10, 10) | 9 (9, 9) | 3 (3, 3) | 5 (5, 5) | 6 (6, 6) | ||
| post_p | 0.17 (0.17, 0.17) | 0.46 (0.46, 0.46) | 0.14 (0.14, 0.14) | 0.32 (0.32, 0.32) | 0.41 (0.41, 0.41) | 0.48 (0.48, 0.48) | 0.5 (0.5, 0.5) | 0.41 (0.41, 0.41) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.038 (0.038, 0.038) | 0.02 (0.02, 0.02) | 0.032 (0.032, 0.032) | 0.038 (0.038, 0.038) | 0.018 (0.018, 0.018) | 0 (0, 0) | 0 (0, 0) | 0.037 (0.037, 0.037) | ||
| TP53- | Hormone_therapies | count | 222 | 222 | 222 | 222 | ||||
| time | 23 (13, 47) | 23 (13, 47) | 23 (13, 47) | 23 (13, 47) | ||||||
| n | 53 (29, 115) | 15 (7, 36) | 13 (6, 33) | 13 (7, 28) | ||||||
| post_p | 0.34 (0.15, 0.47) | 0.42 (0.24, 0.49) | 0.4 (0.18, 0.49) | 0.42 (0.21, 0.49) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.015, 0.027) | 0.023 (0.013, 0.038) | 0.022 (0.013, 0.04) | 0.022 (0.012, 0.037) | ||||||
| Taxel_therapies | count | 221 | 221 | 221 | 221 | |||||
| time | 23 (14, 49) | 23 (14, 49) | 23 (14, 49) | 23 (14, 49) | ||||||
| n | 52 (30, 121) | 16 (8, 35) | 14 (7, 29) | 14 (7, 27) | ||||||
| post_p | 0.37 (0.15, 0.47) | 0.41 (0.23, 0.48) | 0.41 (0.21, 0.49) | 0.4 (0.18, 0.48) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.02 (0.015, 0.025) | 0.022 (0.015, 0.034) | 0.022 (0.013, 0.039) | 0.023 (0.014, 0.039) | ||||||
| Niraparib | count | 21 | 21 | 21 | 21 | |||||
| time | 15 (12, 31) | 15 (12, 31) | 15 (12, 31) | 15 (12, 31) | ||||||
| n | 37 (29, 74) | 10 (6, 18) | 10 (7, 24) | 9 (7, 15) | ||||||
| post_p | 0.34 (0.17, 0.47) | 0.44 (0.24, 0.5) | 0.44 (0.4, 0.5) | 0.45 (0.41, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.021 (0.012, 0.033) | 0.029 (0.016, 0.038) | 0.018 (0.012, 0.038) | 0.019 (0, 0.026) | ||||||
| TP53+ | Hormone_therapies | count | 195 | 195 | 195 | 195 | ||||
| time | 27 (16, 52) | 27 (16, 52) | 27 (16, 52) | 27 (16, 52) | ||||||
| n | 40 (22, 82) | 27 (15, 61) | 12 (6, 26) | 12 (6, 27) | ||||||
| post_p | 0.37 (0.14, 0.48) | 0.37 (0.13, 0.48) | 0.42 (0.22, 0.49) | 0.4 (0.19, 0.48) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.016, 0.027) | 0.022 (0.015, 0.032) | 0.021 (0.012, 0.037) | 0.022 (0.013, 0.038) | ||||||
| Taxel_therapies | count | 198 | 198 | 198 | 198 | |||||
| time | 25 (16, 46) | 25 (16, 46) | 25 (16, 46) | 25 (16, 46) | ||||||
| n | 36 (23, 77) | 25 (15, 53) | 11 (6, 22) | 11 (6, 22) | ||||||
| post_p | 0.34 (0.14, 0.47) | 0.39 (0.17, 0.48) | 0.4 (0.2, 0.49) | 0.43 (0.28, 0.49) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.016, 0.03) | 0.021 (0.015, 0.031) | 0.023 (0.013, 0.04) | 0.021 (0.013, 0.037) | ||||||
| Niraparib | count | 27 | 27 | 27 | 27 | |||||
| time | 20 (14, 33) | 20 (14, 33) | 20 (14, 33) | 20 (14, 33) | ||||||
| n | 32 (21, 56) | 21 (14, 37) | 9 (4, 18) | 10 (5, 17) | ||||||
| post_p | 0.4 (0.24, 0.47) | 0.39 (0.13, 0.47) | 0.44 (0.35, 0.49) | 0.46 (0.43, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.021 (0.017, 0.025) | 0.023 (0.015, 0.031) | 0.021 (0.01, 0.04) | 0.018 (0.007, 0.027) | ||||||
| DRD+ | Hormone_therapies | count | 195 | 195 | 195 | 195 | ||||
| time | 34 (24, 52) | 34 (24, 52) | 34 (24, 52) | 34 (24, 52) | ||||||
| n | 18 (9, 36) | 17 (10, 31) | 14 (8, 29) | 14 (7, 27) | ||||||
| post_p | 0.37 (0.14, 0.47) | 0.35 (0.15, 0.48) | 0.38 (0.18, 0.48) | 0.39 (0.15, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.034) | 0.022 (0.015, 0.037) | 0.022 (0.014, 0.032) | 0.021 (0.014, 0.034) | ||||||
| Taxel_therapies | count | 194 | 194 | 194 | 194 | |||||
| time | 34 (23, 50) | 34 (23, 50) | 34 (23, 50) | 34 (23, 50) | ||||||
| n | 18 (9, 36) | 17 (10, 31) | 14 (8, 27) | 14 (8, 25) | ||||||
| post_p | 0.34 (0.14, 0.47) | 0.36 (0.14, 0.48) | 0.38 (0.13, 0.48) | 0.39 (0.2, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.016, 0.033) | 0.021 (0.015, 0.033) | 0.023 (0.015, 0.038) | 0.021 (0.014, 0.036) | ||||||
| TEfus+ | Hormone_therapies | count | 176 | 176 | 176 | 176 | ||||
| time | 30 (19, 52) | 30 (19, 52) | 30 (19, 52) | 30 (19, 52) | ||||||
| n | 16 (8, 38) | 28 (16, 57) | 15 (8, 29) | 13 (7, 25) | ||||||
| post_p | 0.4 (0.2, 0.48) | 0.36 (0.13, 0.47) | 0.37 (0.15, 0.48) | 0.41 (0.21, 0.48) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.035) | 0.022 (0.016, 0.03) | 0.023 (0.015, 0.039) | 0.022 (0.013, 0.036) | ||||||
| Taxel_therapies | count | 197 | 197 | 197 | 197 | |||||
| time | 29 (19, 50) | 29 (19, 50) | 29 (19, 50) | 29 (19, 50) | ||||||
| n | 18 (10, 38) | 27 (17, 57) | 15 (9, 32) | 12 (7, 23) | ||||||
| post_p | 0.4 (0.16, 0.49) | 0.34 (0.14, 0.48) | 0.4 (0.17, 0.48) | 0.4 (0.23, 0.48) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.016, 0.033) | 0.023 (0.016, 0.031) | 0.021 (0.014, 0.033) | 0.021 (0.014, 0.037) | ||||||
| Niraparib | count | 11 | 11 | 11 | 11 | |||||
| time | 26 (17, 50) | 26 (17, 50) | 26 (17, 50) | 26 (17, 50) | ||||||
| n | 17 (12, 28) | 27 (19, 57) | 19 (11, 23) | 12 (5, 24) | ||||||
| post_p | 0.38 (0.1, 0.47) | 0.44 (0.08, 0.46) | 0.45 (0.33, 0.5) | 0.45 (0.35, 0.49) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.02 (0.015, 0.039) | 0.019 (0.018, 0.031) | 0.014 (0.008, 0.023) | 0.013 (0.005, 0.024) |